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New Treatments and Drugs
Combined Pharmacotherapy and Psychotherapy as Maintenance Treatment
for Late-Life Depression: Effects on Social Adjustment
Eric J. Lenze, M.D., Mary Amanda Dew, Ph.D., Sati Mazumdar, Ph.D., Amy E. Begley, M.A., Cleon Cornes,
M.D., Mark D. Miller, M.D., Stanley D. Imber, Ph.D., Ellen Frank, Ph.D., David J. Kupfer, M.D., and Charles F.
Reynolds, III, M.D.
The following abstract is from the American Journal of Psychiatry. You may read the full article at
ajp.psychiatryonline.org
OBJECTIVE: This study examined the effects of maintenance treatment for late-life depression on social
adjustment. The authors hypothesized that elderly patients recovering from depression would have better
social adjustment with medication and interpersonal psychotherapy than with medication or
psychotherapy alone.
METHOD: Patients aged 60 and older recovering from recurrent major depression were randomly
assigned to one of four treatments: nortriptyline and interpersonal psychotherapy, nortriptyline and clinic
visits, placebo and psychotherapy, or placebo and clinic visits. The Social Adjustment Scale was
administered every 3 months until illness recurrence. Combined treatment was compared to
monotherapy on scores over 1 year among patients who remained in recovery (N= 49).
RESULTS: Patients receiving nortriptyline and interpersonal psychotherapy maintained social
adjustment, which declined in those receiving monotherapy.
CONCLUSIONS: Treatment of late-life depression with nortriptyline and psychotherapy is more likely to
maintain social adjustment than treatment with either alone. Combination therapy improves not only
duration but quality of wellness.
Combined Pharmacotherapy and Psychotherapy as Maintenance Treatment
for Late-Life Depression: Effects on Social Adjustment
Eric J. Lenze, M.D., Mary Amanda Dew, Ph.D., Sati Mazumdar, Ph.D., Amy E. Begley, M.A., Cleon Cornes,
M.D., Mark D. Miller, M.D., Stanley D. Imber, Ph.D., Ellen Frank, Ph.D., David J. Kupfer, M.D., and Charles F.
Reynolds, III, M.D.
The following abstract is from the American Journal of Psychiatry. You may read the full article at
ajp.psychiatryonline.org
OBJECTIVE: This study examined the effects of maintenance treatment for late-life depression on social
adjustment. The authors hypothesized that elderly patients recovering from depression would have better
social adjustment with medication and interpersonal psychotherapy than with medication or
psychotherapy alone.
METHOD: Patients aged 60 and older recovering from recurrent major depression were randomly
assigned to one of four treatments: nortriptyline and interpersonal psychotherapy, nortriptyline and clinic
visits, placebo and psychotherapy, or placebo and clinic visits. The Social Adjustment Scale was
administered every 3 months until illness recurrence. Combined treatment was compared to
monotherapy on scores over 1 year among patients who remained in recovery (N= 49).
RESULTS: Patients receiving nortriptyline and interpersonal psychotherapy maintained social
adjustment, which declined in those receiving monotherapy.
CONCLUSIONS: Treatment of late-life depression with nortriptyline and psychotherapy is more likely to
maintain social adjustment than treatment with either alone. Combination therapy improves not only
duration but quality of wellness.
Dr. Grohol's mental health site is one of the oldest popular site of its kind on the web.
It includes a directory of resources, detailed and accessible information about a wide
range of psychiatric disorders, and lots of links.
It includes a directory of resources, detailed and accessible information about a wide
range of psychiatric disorders, and lots of links.
Revitalizing Psychiatry
What's New